Today’s video goes through a genetic and biochemical analysis of SARS-CoV-2
• Full sequence for Bat-CoV RaTG13 was not known (not in database) prior to the pandemic. The group that isolated Bat-CoV RaTG13 had originally sequenced just the polymerase. Upon a hit with the SARS-CoV-2 polymerase, the group retrieved the frozen isolate (which had remained cryopreserved ever since) to sequence the whole genome. It was at this point the 96% homology was elucidated.
• Link to A pneumonia outbreak associated with a new coronavirus of probable bat origin paper in Nature https://www.nature.com/articles/s41586-020-2012-7
• The above image is from the Netflix original Coronavirus, Explained S1:E1.
Slide 2, 3 and 4:
• Link to The proximal origin of SARS-CoV-2 paper in Nature Medicine https://www.nature.com/articles/s41591-020-0820-9