From the key concepts of mutation to how coronaviruses get into cells- posts on key background information can be found here.
By Jacob L. Fine (Image from here) The world we see is not the world that is. Our sense organs were sculpted by natural selection to help us survive in what the evolutionary biologist Richard Dawkins calls Middle World. He is quick to distinguish this from the J. R. R. Tolkien’s land of hobbits and … Continue reading Overcoming Middle World
References Link to Attenuation of replication by a 29 nucleotide deletion in SARS-coronavirus acquired during the early stages of human-to-human transmission paper in Nature Scientific Reports https://www.nature.com/articles/s41598-018-33487-8 Link to Report of the WHO-China Joint Mission on Coronavirus Disease 2019 (COVID-19) report https://www.who.int/docs/default-source/coronaviruse/who-china-joint-mission-on-covid-19-final-report.pdf Link to Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) … Continue reading Video Sidebar: SARS-CoV-2 VS Other Coronaviruses
Author’s Note The COVID-19 pandemic has created unprecedented challenges for our healthcare heroes. As the on-going pandemic continues, many of our healthcare heroes are continually risking their lives to help fight the battle. I personally wanted to celebrate our healthcare heroes by highlighting research that describes the experiences of healthcare professionals. Thus, I hope this … Continue reading Sidebar: Healthcare Heroes in Wuhan, China
Before we launch into the video, we should first define the term “Divergent Evolution,” which Demitri defines as: When at least 2 groups of the same species that originate from the same parent species independently acquire differences that are necessary for persistence in their respective environments. You can find out more about divergent evolution here. … Continue reading Video Sidebar: Wrapping up- Where Did SARS-CoV-2 come from?
Today’s video goes through a genetic and biochemical analysis of SARS-CoV-2 References: Slide 1:• Full sequence for Bat-CoV RaTG13 was not known (not in database) prior to the pandemic. The group that isolated Bat-CoV RaTG13 had originally sequenced just the polymerase. Upon a hit with the SARS-CoV-2 polymerase, the group retrieved the frozen isolate (which had … Continue reading Video Sidebar: Genetics of SARS-CoV-2
This is the first instalment in a new sidebar series. In this series, I’m going to attempt to list and define some common terms in life science research. The idea is for these posts to act as a reference for anyone who wants to read through a paper that hasn’t been demystified yet. A lot … Continue reading The ABCs of Research (Science to English Dictionary: Part 1)
Today’s video goes over basic coronavirus taxonomy and some of the details on SARS-CoV-2 origins Editor’s notes: 3:10: Although the text at the bottom of the slide refers to D614G as a mutation, the better word for it would be an ‘amino acid change.’ The word mutation refers to a change in genetic code, while … Continue reading Video Sidebar: SARS-CoV-2 Taxonomy and Origins
Dear readers, For those of you in British Columbia, Happy BC Day! We hope you enjoy your long weekend while staying safe. Wear a mask when you’re in public and stay 6′ apart! COVID19 Demystified is coming up on its fifth month of operation. When we started this initiative we weren’t think about how long … Continue reading Letter From the Editor: August, 2020
To biology students everywhere, the principles of the central dogma of molecular biology are only too familiar. Today I’m going to take you through a basic overview of these principles. I’m going to explain what the central dogma is and each of the steps that it describes. Ready? Here we go. What is it? The … Continue reading Sidebar: The Central Dogma of Molecular Biology
Dear Readers, I’d like to start by wishing you a happy Canada Day! COVID19 Demystified is a Canadian initiative at its heart, although it has now grown to include people from around the world. The spirit of international collaboration that has taken over this project is also a deeply Canadian concept, and we are proud … Continue reading Letter From the Editor: July 2020
COVID19 Demystified is all about us reading scientific papers and giving you, our readers, a breakdown of the critical findings, conclusions and limitations. That being said, there are plenty of papers out there that aren’t on COVID19, and those papers are pretty awesome. In this post, I’m going to walk you through the basic steps … Continue reading Sidebar: Tips and tricks for reading a scientific paper
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